It functions in stoichiometric relationships forming heterotrimeric complexes with cycling and cyclin-dependent kinases.

其功能与周期蛋白和周期蛋白依赖性激酶形成的异源三聚体存在化学计量关系。

Cyclin B1, Rabbit anti-Hamster, Mouse, Hamster, Human.

周期素b 1，兔抗仓鼠，小鼠，仓鼠，人。

Objective To investigate the expression of cyclin-dependent kinase-2 (CDK-2) gene in SH-SY5Y cells.

目的观察细胞周期蛋白依赖性激酶- 2 (CDK - 2)在SH - SY5Y细胞中的表达情况。

AIM To analyze the expression and significance of cyclin dependent kinase 4 (CDK4) in chondrosarcoma of the jaws.

目的分析细胞周期素依赖激酶4 (CDK4)在颌骨软骨肉瘤的表达及意义。

AIM: to construct the recombinant expression vector and to obtain large amount of mouse Cyclin D1 protein fused to PTD.

目的：构建融合重组表达载体并对其进行诱导表达和蛋白纯化以获得大量重组融合蛋白。

Results Rabbit smooth muscle cells could express cyclin d, the reactant of immune reaction was mainly located in nuclei.

结果发现，主动脉平滑肌细胞可表达细胞周期素d，其免疫反应产物主要位于细胞核内。

Monoclonal antibody is produced by immunizing animals with recombinant human cyclin D3 corresponding to residues 241-260.

该单克隆抗体是由重组的人源的针对cyclin D3 241 - 260氨基酸残基免疫动物而生产的。

Conclusion Ribozyme targeting cyclin Dl may effectively inhibit cyclin D1 expression and activation in the HSC T6 cell line.

结论载体表达的特异性核酶能有效地抑制HSC的细胞周期蛋白d1的表达和激活。

AIM: To evaluate the relationship between RUNX3, cyclin e, P21, biological features and survival in gastric cancer patients.

目的：探讨胃癌RUNX3蛋白表达对细胞周期蛋白的影响及其与胃癌患者生存和生物学特性的关系。

To investigate the effect of benazepril on expression of cyclin kinase inhibitor P21 CIP1 protein in renal tissue of diabetic rats.

目的：探讨苯那普利对糖尿病大鼠肾组织细胞周期蛋白激酶抑制剂p 21 CIP1蛋白表达的影响。

Our results indicated that there were at least 49 predicted rice cyclin genes in the rice genome, and they were distributed on 12 chromosomes.

我们的 结果表明，有至少49个预测的水稻细胞周期蛋白基因在水稻基因组，它们被分布在 12条染色体。

Both clones included a DNA sequence that allow a fluorescent protein expressed in the cell to bind to cyclin D1 RNA the moment it is transcribed.

这两个克隆都包含有一段DNA序列，能在在细胞周期蛋白d1的RNA被转录的时候将荧光蛋白绑定到其上。

Objective To observe the expression of cyclin kinase inhibitor P16 in pterygium and to investigate its effects on the pathogenesis of pterygium.

目的探讨翼状胬肉组织中细胞周期蛋白依赖性激酶抑制剂P16的表达，了解其在翼状胬肉发病机制中的作用。

We identified several types of cyclin genes in the rice genome and characterized them by phylogenetic, tandem and segmental duplications analyses.

我们确定了几个类型在水稻基因组的细胞周期蛋白基因和特征的系统发育，串联重复片段的分析。

Objective To explore the inhibition of expression of cyclin E1 in hepatocellular carcinoma via RNA interference mediated by siRNA expressing vector.

目的探讨经载体介导的RNA干扰对肝癌细胞周期蛋白E1表达抑制效率。

Objective in the present study, we tried to further elucidate the expression and function of cyclin D1 in human nasopharyngeal carcinoma (NPC) cell line.

目的深入研究周期蛋白d 1在鼻咽癌细胞中的表达特征及其生物学功能。

CONCLUSION: the high amplification of Cyclin D1 and the high deletion of P16 gene is closely related to the high activity of proliferation of lung cancer.

结论：细胞周期素d1的扩增和P 16的缺失与肺癌细胞的高增殖活性密切相关。

Cyclin D1 which functions as a mitogenic sensor and allosteric activator of CDK4/6, is one of the more frequently altered cell cycle regulators in cancers.

细胞周期蛋白D1作为一个能促进有丝分裂和CDK4的变构激活剂，是癌症中较频繁变化的细胞周期调节子。

Objective: to investigate the relationship between the cyclin kinase inhibitor P27 and the protective effect of quercetin on the diabetic glomerulus in rats.

目的：探讨槲皮素对糖尿病肾病的影响及该影响与肾小球周期素激酶抑制剂p27的关系。

The changes in cyclin synthesis and MPF activity during oocyte maturation in vitro in gynogenetic silver crucian carp and amphimictic colored crucian carp were compared.

采用体外诱导卵母细胞成熟技术，比较研究了雌核发育银鲫和两性融合发育彩鲫卵母细胞成熟过程中周期蛋白合成和MPF活性变化情况。

Levels of cyclin D protein drop upon withdrawal of growth factors through downregulation of its protein expression and through phosphorylation-dependent degradation (4).

生长因子退出后，通过下调蛋白表达和磷酸化依赖性蛋白降解，周期蛋白D的水平下降（4）。

METHODS: Method of multiplex polymerase chain reaction (PCR) was adopted. Cyclin D1 gene and P16 gene were amplified in the same tube, using extracted genome DNA as template.

方法：采用多重聚合酶链反应方法，以提取的基因组d NA为模板，在同一反应管中同时扩增细胞周期素d 1基因和P 16基因。

Cyclin D1 is frequently over-expressed in cancers and its overexpression can be attributed to many factors including increased transcription, translation, and protein stability.

细胞周期蛋白d1在癌症中经常过表达，可引起其过表达的因素很多，包括增加转录，翻译和蛋白质的稳定性。

Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle.

周期素d 1编码一种全酶的调节亚单位，该酶利用蛋白磷酸化灭活视网膜母细胞瘤蛋白，通过细胞周期G 1 - S期促进肿瘤进展恶化。

The active complex of cyclin D/CDK4 targets the retinoblastoma protein for phosphorylation, allowing the release of E2F transcription factors that activate G1/S-phase gene expression (3).

活跃的cyclin D/CDK4复合体靶向视网膜母细胞瘤蛋白以利于磷酸化，促进可以激活G1/S期基因表达的转录因子E2F的释放（3）。

The entry of eukaryotic cells into mitosis is regulated by cdc2 kinase activation, a process controlled at several steps including cyclin binding and phosphorylation of cdc2 at Thr161 (1).

cdc2蛋白激酶的激活参与调节真核细胞进入有丝分裂，cdc2的激活受多个步骤的调控，包括周期蛋白的结合、cdc2苏氨酸161位的磷酸化(1)。

Cell Cycle Progression through the cell division cycle and transitions between various phases are regulated by using CDC25 phosphatases to activate specific cyclin-dependent kinase(CDK) complexes.

细胞分裂周期运行和不同时相的转换通过CDC25磷酸酶去磷酸化和激活周期蛋白依赖性激酶（CDK）复合物来调控。

They found that the asymmetric activation of one EGFR kinase domain by another is analogous to the activation of cyclin-dependent kinase (CDK) by cyclin, which are involved in regulating cell growth.

他们发现，由一个分子对另外一个EGFR激酶结构域的不对称激活类似于涉及调控细胞生长的细胞周期蛋白激活细胞周期蛋白依赖型激酶的方式。