The defective mismatch repair system may result in mutations of genome and cause tumors.

错配修复系统缺陷可能导致遗传物质发生突变，引发恶性肿瘤。

But the large loop repair, a distinct repair from mismatch repair, is an unknown repair system.

但是大型核酸环的修复，一个迥异于配对错误的修复机制，却是个未知的系统。

This paper reviewed the relationship between DNA mismatch repair, chromosome instability and cancer.

本文就DNA错配修复、染色体不稳定和肿瘤之间的联系予以综述。

In several but not all cases, mutators have been found to contain defects in mismatch repair (MMR) pathways;

在一些但不是所有情况下，存取器已被发现含有缺陷的错配修复（MMR）途径；

When function defects of mismatch repair genes, Cell Showes Genomic instability because of the aggregation of mutation.

错配修复基因功能缺失时，细胞常会因基因突变聚集而表现为遗传不稳定。

DNA mismatch repair system could recognize and repair mistakes in process of DNA replication, guard stability and integrality of genome.

DNA错配修复系统可以识别并纠正DNA复制过程中出现的错误，保证基因组的稳定性和完整性。

The overwhelming majority of traditional serrated adenomas retain mismatch repair enzyme function indicating a microsatellite-stable phenotype.

绝大多数传统锯齿状腺瘤保留错配修复酶功能，表明微卫星稳定表型。

Background Surgical management of colon cancer for patients with Lynch syndrome who carry a mismatch repair (MMR) gene mutation is controversial.

背景对那些携带错配修复(MMR)基因突变且有林奇综合症的结直肠癌患者来说，手术方式是有争议的。

Consequence of homologous recombination, in which hybridization between different alleles causes one allele to be converted into the other. This occurs by mismatch repair.

同源重组的后果，在不同等位基因之间的杂交使其中的一个等位基因被转换成了另一个等位基因。这是由错配修复引起的。

In gastrointestinal adenocarcinomas, PD-L1-expression was associated with EBER positivity and mismatch-repair deficiency.

胃肠道腺癌中，PD-L1表达与EBER阳性和错配修复缺陷相关。