The objective is to observe the expression of MMP-1and TIMP-1 in nucleus pulposus cells of intervertebral disc degeneration.

目的是测定 MMP-1 及 TIMP-1 在人退变椎间盘髓核中的表达。

The function of TIMP-1 in cell cycle regulation was analyzed.

对TIMP - 1在细胞周期调控中的作用进行了分析。

The nuclear distribution of TIMP-1 in liver cancer cells was observed.

首次发现TIMP-1在肝癌细胞中的核内分布现象。

Their activities are inhibited by the tissue inhibitor of metalloproteinase (TIMP).

其活性受到特异性金属蛋白酶抑制剂(TIMP)的抑制。

In this paper, the property, structure, and function of MMP and TIMP were reviewed.

本文就基质金属蛋白酶及其组织抑制剂的性质、结构以及功能进行了综述。

To evaluate significance of serum levels of MMP-9 and TIMP-1 as serum target of plaque rupture.

评价血清mmp 9及TIMP 1水平作为粥样斑块破裂的血清学指标的意义。

Objective To study the expression and significance of MMP-2 and TIMP-2 in colorectal carcinoma.

目的探讨基质金属蛋白酶-2（MMP-2）和组织基质金属蛋白抑制剂-2（TIMP-2）在大肠癌组织中的表达及其意义。

There was significant difference in serum level of MMP-9 and TIMP-1 between ACS, SAP, and control group.

SAP组血清mmp 9水平高于正常对照组，而血清TIMP 1水平低于正常对照组，也具有统计学意义。

Conclusions Overexpression of TIMP-1 exacerbates renal tubulointerstitial injury by enhancing inflammation.

结论TIMP - 1过表达可通过增强炎症加重肾小管间质损伤。

Objective To investigate the effects of overdosed fluoride on the expression of MMP-20 and TIMP-2 in rat incisor.

目的研究过量氟对大鼠切牙生长过程中基质金属蛋白酶-20（MMP-20）和基质金属蛋白酶组织抑制剂-2（TIMP-2）表达的影响，探讨氟斑牙的发病机制。

Methods MMP-9 and TIMP proteins were examined by using zymographic analysis and Western blot in 41 cases with ESCC.

方法免疫组化法分别检测41例食管鳞癌患者的癌及相应正常组织中MMP-9和TIMP的表达变化。

Gene TIMP-2 has inhibitory effect to the changes of biology and morphology in guinea pig form deprivation myopia model.

因此TIMP - 2基因对于豚鼠形觉剥夺性近视模型形态学和生物学改变有一定的抑制效应。

Results (1) There were no significant negative relationships between MMP-1, TIMP-1 and BMD and bone biochemical markers.

结果（1）绝经后妇女血清MMP-1、TIMP-1水平与骨密度、骨转换生化指标无明显相关性。

Expression of Matrix Metalloproteinase-2, -9 and Their Inhibitors TIMP-1, -2 on Lens Epithelial Cells of Aged-related Cataract.

基质金属蛋白酶- 2,9及其抑制因子- 1,2在老年性白内障晶状体上皮细胞的表达。

Conclusion TIMP-1 expression increased in hepatic fibrosis. IL-10 exhibit an antifibrogenic effect by suppressingTIMP-1 expression.

结论TIMP 1随着大鼠肝纤维化进展表达逐渐升高，IL 10通过抑制TIMP 1的表达，起抗纤维化作用。

Objective To investigate the relationship between the ratio of MMP-3 to TIMP-1 and articular cartilage injury after ischemia-reperfusion.

目的探讨缺血再灌注后关节软骨中MMP - 3/TIMP - 1比例变化与软骨损伤的关系。

Results the MMP-2 and TIMP-2 expression levels in the carotid tissues of the control group was low, and elevated in the experimental group.

结果MMP - 2和TIMP - 2在对照组兔颈动脉组织中低水平表达，在实验组兔颈动脉组织中表达的水平升高。

Purpose To understand the relationship between the expression of MMP-2, TIMP-2 and the clinical significance in human colorectal carcinoma.

目的研究基质金属蛋白酶-2（MMP-2）及其抑制物组织基质金属蛋白酶抑制剂-2（TIMP-2）在大肠癌进展中的作用及其临床意义。

Objective To investigate the expression of the tissue inhibitor of metalloproteinases (TIMP) in human esophageal squamous cell carcinoma(ESCC).

目的探讨组织金属蛋白酶抑制剂（T IMP）在食管鳞癌中的表达及其临床意义。

ConclusionThe expression of MMP-2, TIMP-1 and TIMP-2 are closely correlated with the development of the invasive activity of human astrocytoma.

结论MMP - 2、TIMP - 1和TIMP - 2在星形细胞肿瘤组织中的表达与星形细胞肿瘤的侵袭性生物学行为的演进密切相关。

Objective To investigate the action of recombinant protein of tissue inhibitor of metalloproteinase-3(TIMP-3)on apoptosis of MC3T3-E1 osteoblasts.

目的研究组织金属蛋白酶抑制因子3（TIMP-3）重组蛋白对MC3T3-E1成骨细胞凋亡的影响。

Objective to study the expression of MMP 2 and TIMP 2 in gastric cancer tissues and the relation to the aggregated degree, metastasis and prognosis.

目的探讨基质金属蛋白酶- 2 (MMP - 2)和组织基质金属蛋白抑制剂- 2 (TIMP - 2)在胃癌组织中的表达及其与侵袭程度、淋巴结转移的关系。

Objective: To construct and identify recombinant adeno-associated virus encoding rat tissue inhibitor of metalloproteinase-1(TIMP-1) full length cDNA.

目的：构建及鉴定载入金属蛋白酶组织抑制因子1（TIMP鄄1）的重组腺相关病毒载体。

Results The results of immunohistochemistry and double immunofluorescence showed that TIMP-1 was positive in vascular endothelial cells of normal muscles.

结果免疫组织化学和双免疫荧光标记结果显示TIMP-1在正常肌肉的血管内皮细胞处表达；

Oral administration and local injection of tea polyphenol could markedly reduce expression of VEGF and increase expression of TIMP-2 in S180 bearing tumor.

茶多酚口服及局部注射组可明显降低S180荷瘤vegf表达水平、增加TIMP - 2表达水平。

Conclusion MMP-2, MMP-9 and TIMP-1 play an important role in the infiltrative metastasis of seminoma and may act as one of the factors to evaluate prognosis.

结论MMP - 2、MMP - 9、TIMP - 1在人睾丸精原细胞瘤的浸润转移过程中起重要作用，有可能成为估计预后的指标之一。

AIM: to investigate the expression of MMP 2 and TIMP 2 in tumor invasion and local metastasis or as a prognostic factor in patients with pancreatic carcinoma.

目的：研究MMP 2, TIMP 2在胰腺癌组织中的表达，探讨其与胰腺癌的侵袭转移及预后的关系。

Objective To study the significance of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) expressing in craniopharyngiomas.

目的 研究基质金属蛋白酶MMP-2及其抑制剂TIMP-2在颅咽管瘤中的表达意义。

Objective To determine the relationship between the expression of tissue-inhibitors of metalloproteinases-1 (TIMP-1) and the prognosis of laryngeal carcinoma (LG).

目的：研究金属蛋白酶组织抑制因子1（TIMP-1）在喉癌中的表达情况及其与喉癌预后的关系。

Conclusion the serum mediated with TCM liver-protective drugs could inhibit the TIMP-1 expression of hepatic HSC and promote apoptosis of the activated hepatic HSC.

结论保肝中药复方药物血清能抑制肝星形细胞TIMP 1的表达，并促进活化的肝星形细胞凋亡。