"What's up?" I said to him.—"Just tired," he answered.

“出了什么事？”我对他说。— “只是累了，”他答道。

What's up with you, chuck?

你怎么了，亲爱的？

What's up with him? He looks furious.

他怎么了？他看上去怒气冲冲。

Hey, dude, what's up?

喂，哥们儿，怎么啦？

What's up?

怎么了？

I'm at home. What's up?

我在家。怎么了？

You look a little unhappy. What's up?

你看起来有点不开心。怎么了？

What's up with the mime act?

哑剧表演是怎么回事？

What's up? What is this car for?

出什么事了？这车是干嘛的？

What's up? Wait a minute, please.

怎么了？请等一下。

What's up with ice cream headaches?

吃冰淇淋头疼是怎么回事？

What's up? Bro. What's in the bulletin?

怎么啦？弟弟。布告栏上面说的是什么啊？

What's up, guys?

小伙子们，怎么样？

I have nothing to do tomorrow afternoon. What's up?

我明天下午没事做。有什么事吗？

Steven: So tell me, what's up?

史蒂文： 好吧， 告诉我， 什么事？

So, what's up with the weather?

那么，天气究竟怎么了？

M: Hi, Sarah, what's up?

M：嗨，莎拉，你好吗？

But what's up with my shoulders?

不过我的肩膀是咋了？

What's up, John? (Laughter.)

(笑声)怎么了，约翰？

So what's up with Norway and Australia?

那挪威和澳大利亚为什么会这样呢？

What's up with him today?

他今天怎么了？

Steven: Well, not really. What's up?

史蒂文：嗯，其实没什么空，你有事吗？

A: Hi, John. What's up?

嗨，约翰，最近好吗？