Do you think JNK is a treatment target for diabetes?

您认为JNK是糖尿病的一个治疗靶点吗？

JNK signaling transduction pathway plays a vivtal role in the neuronal apoptosis.

JNK信号转导途径参与神经元凋亡。

In this review, we focus on JNK-mediated signaling pathways and the role of ROS in these pathways.

本文将主要总结JNK介导的信号转导途径及活性氧在这一途径中所发挥的作用。

Conclusion The activation of JNK signaling pathway may play an important role in t lymphocyte proliferation.

结论JNK信号通路的活化在小鼠T细胞增殖中可能起着重要作用。

The Yale team found that the JNK stress signaling travels from one cell to the next, but that the propagation can be blocked.

耶鲁研究小组发现JNK应激信号从一个细胞向另一个细胞传导，但这个传导途径能被阻断。

Objective: To explore the mechanism of JNK pathway regulating proliferation of hepatic stellate cells(HSC) stimulated by acetaldehyde.

目的：初步探讨JNK信号通路调控乙醛刺激的大鼠肝星状细胞（HSC）增殖的分子机制。

Conclusion: It is suggested that JNK has effects on proliferation of HSC stimulated by acetaldehyde and JNK maybe an important signal pathway regulating HSC proliferation.

结论：JNK活性变化与乙醛刺激的大鼠hsc的增殖具有相关性，提示JNK可能是调节hsc增殖的重要信号通路之一。

Conclusion Inhibition of chronic morphine-induced spinal JNK activation may be one of the mechanisms underlying the blockage of morphine antinociceptive tolerance by agmatine.

结论抑制慢性吗啡注射所引起的脊髓jnk的激活可能是胍丁胺抗吗啡镇痛耐受的作用机制之一。

CONCLUSION: Acetaldehyde causes oxidative damage in cardiomyocytes through enhancing cellular ROS level, and induces cardiocytes apoptosis by activating ROS mediated JNK pathway.

结论：乙醛通过增高胞内ros水平损伤心肌细胞，激活ros介导JNK途径诱导细胞凋亡。