Methods: The rabbit model of acute soman intoxication was established.

方法：建立兔急性梭曼中毒模型。

Objective: To observe the neurotoxicity of hypoxia at high altitude in combination with soman intoxication .

目的：通过模拟高原缺氧复合梭曼中毒，观察缺氧、梭曼中毒复合效应的神经毒作用。

As CNS lesions were closely correlated with convulsions, anticonvulsants must be used after soman poisoning.

由于CNS病变与惊厥有密切关系，因此梭曼中毒后必须应用抗惊剂。

These results indicate that the anaerobic VX-metabolizing enzyme is different from soman and paraoxon hydrolases.

冻融使VX 非氧化代谢酶活性丧失，但不影响对氧磷水解酶的活性。

AIM: This study was to utilize cholinergic antagonists to examine cholinergic pathway of soman-induced hypothermia.

目的：本研究使用胆碱能阻断剂探讨梭曼引起降温作用的胆碱能途径。

To know the abzyme mechanism of soman hydrolysis, the structure-activity relationship of soman and abzyme was studied.

为了解其催化水解梭曼的机制，需对其进行构效关系研究。

Objective: to determine the characteristic of the changes of rats heart function due to soman intoxication in hypoxia.

目的：探讨缺氧条件下梭曼中毒大鼠心脏功能的变化特点。

The results showed that HI-6 delayed treatment is effective to reactivate the acetylcholinesterase inhibited by soman.

所以，HI—6延迟治疗对提高胆碱酯酶活力是有效的。

Objective: to explore the role of calcium in the injury of nerve cells induced by soman intoxication and its mechanism.

目的：探索钙在梭曼中毒神经细胞损伤中的作用及其机理。

Objective: to observe the changes of the activity of catecholamine neuron groups in the brain stem after acute soman intoxication.

目的：观察梭曼急性中毒后脑干儿茶酚胺神经元的活动变化。

Methods the ways of skin injury of ultraviolet radiation skin permeation of soman and section of skin tissues were used for the study.

方法通过梭曼的离体透皮吸收、紫外线照射致皮肤损伤和组织切片方法进行这两种皮肤特点的比较。

The combined injury of hypoxia and soman poisoning is a kind of specific chemical injury which maybe occurs in the high altitude area.

高原缺氧复合梭曼中毒是可能发生在高原地区的一种特殊化学伤害。

In previous studies we found that the toxicity of soman was increased by hypoxia exposure but the mechanism was not clearly underlined.

本室既往研究表明，高原缺氧条件下梭曼毒性明显增加，但原因尚未完全阐明。

AIM to study if the species difference of soman toxicity is related to the diversity of soman binding to different animal plasma and RBC.

目的研究不同种属动物梭曼毒性差异是否与血浆及红细胞与梭曼结合差异有关。

Objective:To study the therapeutic mechanism of ultraviolet blood irradiation and oxygenation(UBIO) for acute soman intoxication in rabbits.

目的：探讨紫外线照射充氧自血回输（UB IO）治疗梭曼急性中毒的机理。

Results:There were dramatically injurt effects on heart function in rats after treated with soman or hypoxia or soman combined with hypoxia.

结果：缺氧条件下梭曼中毒大鼠心脏功能明显抑制，缺氧对心脏舒张功能的影响更为明显，梭曼中毒对心脏收缩功能的抑制严重。

Objective: to study the effect of autotransfusion of ultraviolet-irradiated blood (AUVIB) on (antioxidation) ability in rabbits poisoned by soman.

目的：探讨紫外线照射自血回输疗法(AUVIB)对梭曼中毒家兔抗氧化能力的影响。

Objective to explore the roles of muscarinic acetylcholine receptor (m receptor) in rat brain injuries after soman intoxication combined with hypoxia.

目的探讨毒蕈碱样乙酰胆碱受体(M受体)在缺氧复合梭曼中毒脑损伤中的作用。

AIM to study the relationship between the capability of soman detoxification of blood and the detoxifying enzyme activities in blood of different species.

目的研究不同种属动物及人血液对梭曼的解毒能力与血液中几种梭曼解毒酶活性的关系。

Objective To study the therapeutic effect of autotransfusion of ultraviolet-irradiated blood(AUVIB) on the pulmonary damage due to soman intoxication in rabbits.

目的探讨紫外线照射自血回输（AUVIB）疗法对梭曼染毒家兔肺损伤的治疗作用。

Objective to investigate the effect of ultraviolet blood irradiation and oxygenation (UBIO) on the metabolism of oxygen free radicals in rabbits with acute soman intoxication.

目的探讨紫外线照射充氧自血回输(UBIO)对家兔急性梭曼中毒后氧自由基代谢的影响。

CONCLUSION: Nimodipine might alter the distribution of soman and reduce the initial concentration of soman in rabbit blood, then accelerated the metabolic detoxication of soman.

结论：尼莫地平可能通过改变梭曼的分布，降低了血中梭曼的初始浓度而起到促进梭曼代谢解毒的作用。

The results indicated that the inhibitory effect of Soman on the medullary respiratory centre was much stronger than that of Sarin, while VX was the weakest of three inhibitors.

结果表明：梭曼对呼吸中枢作用最强、沙林次之、VX最弱且更似乙酰甲胆碱。

Methods Experimental Wistar rats were randomly divided into four groups:normal control group, high altitude hypoxia group, plain soman intoxication group and soman intoxication combined hypoxia group.

方法实验大鼠随机分为正常对照组、高原缺氧组、平原中毒组和缺氧中毒组。

Soman, an organophosphate compound, famous for its high toxicity in animals and human beings, difficulty in prevention and treatment, is one of the chemical warfare agents with a large military stock.

梭曼属有机磷酸酯类化合物，具有毒性大、作用快、中毒难防难治等特点，是外军装备的主要化学战剂之一。