Aurora a is involved in centrosome separation, maturation, and spindle assembly and stability.

Aurora a涉及到中心体分离，成熟和纺锤体聚集以及稳定。

Aurora a is involved in centrosome separation, maturation, and spindle assembly and stability.

极光激酶A参与中心体分离、成熟和纺锤体组装及稳定。

IntroductionThe centrosome is the major microtubule organizing center (MTOC) of mammalian cells.

中心体是哺乳类细胞主要的微管组织中心。

Malfunctions in centrosome cohesion and separation, in fact, have been seen in many solid tumors.

事实上，在很多实体瘤中都发现过中心体连接和分离的机能失常。

They form a connection between the starting point in the chromosomes, the kinetochore, and the centrosome.

他们将染色体、着丝粒和中心体的起点连接起来。

The coordination of the centrosome cycle and cell cycle ensures an accurate distribution of genetic material.

中心体周期和细胞周期相互配合以保证遗传物质的精确分配。

Overexpression of STK15 induces increased Numbers of centrosome, aneuploidy, and transformation of the cells.

STK15过表达诱导中心体数目增多，异倍体形成和细胞转化。

Many centrosome-related proteins and kinases have been found to regulate different steps of centrosome duplication.

现已发现了许多中心体蛋白及与中心体复制相关的蛋白激酶，调控着中心体复制的各个步骤。

With development of the research, the complicated function of centrosome and its im-portance have gradually been realized.

随着研究的进展，人们不断认识到中心体的复杂功能及其重要性。

The study of regulation mechanism about centrosome replication can play an important role in early diagnosis and treatment of tumor.

研究中心体复制调控机制，对肿瘤的早期诊断和治疗有重要的作用。

So gene instability of tumor cells may be closely correlated with centrosome abnormality, which is a common feature of malignant tumor cells.

因此肿瘤细胞基因不稳定可能与中心体异常密切相关。中心体异常是恶性肿瘤细胞的普遍特征。

Prior to cell division it replicates, and the sister centrioles move to opposite ends of the cell to lie within the spindle - organizing structure, the centrosome.

它在细胞分裂之前复制，其中一个中心粒移向细胞的另一端，组织纺锤体和中心体。

The centrosome, the major microtubule organizing center regulates cell division through forming bipolar mitotic spindles and plays an essential role in the maintenance of chromosomal stability.

中心体作为细胞的主要微管组织中心，在细胞周期过程中建立两极纺锤体，调节细胞有丝分裂，从而对维持染色体的稳定起着重要的作用。

More and more importance is attached to the correlation between centrosome abnormity and tumorigenesis, it refers to multiple genes abnormity, mainly separated into oncogene and tumor suppressor gene.

中心体异常与肿瘤发生的相关性已越来越受到人们的重视。