HIF - 1 could become an effective target for cancer treatment in the near future.

HIF - 1可望在将来成为治疗肿瘤的有效靶点之一。

The regulation of HIF 1 activity is the focus of hypoxia responsive genes expression.

HIF 1自身活性调节是低氧应答基因表达调控的中心环节。

This paper reviews the production of ROS and its role in the regulation of HIF activity.

本文主要就ROS 的产生及其对HIF活性调节方面的文献进行综述。

Thus, we pursued HIF-1 as a central component of cardioprotection by ischemic preconditioning.

因此，我们把HIF-1作为缺血预处理心脏保护中的核心成分继续追踪。

It is necessary to establish a hypoxia model for HIF and to perform further hypoxia tolerance research.

有必要建立一种相关缺氧模型，用于HIF和缺氧耐受性的研究。

Finally, the invention also provides methods for the inhibition of VEGF and other HIF-1 regulated proteins.

最后，本发明还提供用于抑制VEGF和其他HIF - 1调节的蛋白质的方法。

Hypoxia-inducible factor (HIF) is an important transcriptional factor, which plays crucial role in response to hypoxia.

乏氧诱导因子(HIF)是乏氧应答中起重要作用的转录因子，一直是乏氧研究的焦点。

In this review, we summarize and discuss mechanisms by which HIF interferes with the different vascular remodeling processes.

在此综述中，我们总结并讨论了有关低氧诱导因子干预不同血管重建过程的机制。

Hypoxia activates hypoxia-inducible factor 1 (HIF-1), thus it controls a series of expression of genes correlated with hypoxia.

低氧可激活低氧诱导因子(HIF - 1)，从而调控一系列与缺氧相关基因的表达。

Hypoxia inducible factor-l (HIF-1), which can stimulate expression of hypoxia induced-responsed, is a kind of transcriptive factor.

缺氧诱导因子- 1 (H IF - 1)是由低氧等诱导细胞产生的1种转录因子，能激活许多缺氧反应性基因的表达。

This review summarized the biological characteristics of HIF-1 and current status of research on the role of HIF-1 in development...

该文就缺氧诱导因子- 1的生物学特性和在宫颈癌中的研究现状作以概述。

The influencing of some oncogene and anti-oncogene to the expression and activity of HIF-1 determines neoplastic prognosis ultimately.

而某些癌基因和抑癌基因对HIF-1表达及活性的影响最终决定着肿瘤的预后。

The anti-hepatoma mechanism of YC-1 through HIF-1 and vascular endothelial growth factor mediation has been a research focus in recent years.

YC-1通过HIF-1和血管内皮细胞生长因子介导的抗肝癌作用已成为近年来的研究重点。

HIF-1 plays crucial roles in oxygen homeostasis, cell energy metabolisms, tumor angiogenesis and metastasis, cell proliferation and apoptosis.

其在维持氧稳定、细胞能量代谢、肿瘤血管生成及转移、细胞增殖与凋亡等诸多方面起着重要作用。

Hypoxia inducible factor-1 (HIF-1) is a key oxygen-dependent transcription factor that up-regulates many protective genes against hypoxia-induced injury.

低氧诱导因子1 (HIF - 1)是重要的氧依赖性核转录因子，低氧条件下能上调多个靶基因表达以减少缺氧性损伤。

Tumor growth and angiogenesis are correlated with the expression of HIF-1, therefore, inhibiting the activity of HIF-1 may be a strategy for cancer therapy.

肿瘤的生长和血管生成与HIF - 1的表达紧密相关，抑制HIF - 1活性可能是治疗癌症的一种途径。

Hypoxia-inducible factor-1(HIF-1), a newly discovered factor in recent years, is an important transcription factor which can control the cells′adaptive responses to hypoxia.

缺氧诱导因子1（HIF-1）是近年发现的调控细胞低氧适应性变化的重要转录因子。

In particular, inhibition of E2-EPF5 activity is shown to reduce the production VEGF, as well as other proteins regulated the transcription factor HIF-1, in response to hypoxia.

具体地，本发明显 示E2-EPF5活性的抑制降低VEGF以及其他在低氧应答中由转录因子 HIF-1调节的蛋白质的产生。

To investigate the spatiotemporal expression of hypoxia-inducible factor-1 (HIF-1) during murine neurulation and explore the role of HIF-1 in the embryonic development of the nervous system.

为研究低氧诱导因子- 1 (HIF - 1)在小鼠胚胎神经胚形成阶段的时空表达规律，探讨HIF - 1在胚胎神经系统发生和发育过程中的作用。